Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus
Joint Authors
Li, Xia
Wang, Dandan
Geng, Linyu
Zhang, Jiyun
Chen, Jinyun
Liu, Rui
Chen, Haifeng
Sun, Lingyun
Feng, Xuebing
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, and immune modulation.
Considering that migration capacity is important for the exertion of BMSCs functions, the defects in migration might contribute to BMSCs dysfunction in SLE patients.
In this study, we showed that the migration capacity of SLE BMSCs was remarkably impaired in comparison with those of healthy controls.
Increased tumor necrosis factor α (TNF-α) in SLE serum significantly inhibited the migration capacity and in vivo homing capacity of SLE BMSCs via a specific TNF receptor I (TNFRI) manner, in which decreased HGF mRNA production caused by the activation of I kappa B kinase beta (IKK-β) pathway is partially involved.
To our knowledge, this is the first report to discuss the possible mechanisms for impaired migration of BMSCs in SLE patients.
Our results suggest that inhibition of TNF-α pathway might be helpful for accelerating BMSCs migration to the inflammatory microenvironment in SLE patients, thereby having a potential role in SLE treatment.
American Psychological Association (APA)
Geng, Linyu& Li, Xia& Feng, Xuebing& Zhang, Jiyun& Wang, Dandan& Chen, Jinyun…[et al.]. 2014. Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040782
Modern Language Association (MLA)
Geng, Linyu…[et al.]. Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040782
American Medical Association (AMA)
Geng, Linyu& Li, Xia& Feng, Xuebing& Zhang, Jiyun& Wang, Dandan& Chen, Jinyun…[et al.]. Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040782