Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity
Joint Authors
Selvan, Senthamil R.
Erkes, Dan A.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Abstract EN
Haptens are small molecule irritants that bind to proteins and elicit an immune response.
Haptens have been commonly used to study allergic contact dermatitis (ACD) using animal contact hypersensitivity (CHS) models.
However, extensive research into contact hypersensitivity has offered a confusing and intriguing mechanism of allergic reactions occurring in the skin.
The abilities of haptens to induce such reactions have been frequently utilized to study the mechanisms of inflammatory bowel disease (IBD) to induce autoimmune-like responses such as autoimmune hemolytic anemia and to elicit viral wart and tumor regression.
Hapten-induced tumor regression has been studied since the mid-1900s and relies on four major concepts: (1) ex vivo haptenation, (2) in situ haptenation, (3) epifocal hapten application, and (4) antigen-hapten conjugate injection.
Each of these approaches elicits unique responses in mice and humans.
The present review attempts to provide a critical appraisal of the hapten-mediated tumor treatments and offers insights for future development of the field.
American Psychological Association (APA)
Erkes, Dan A.& Selvan, Senthamil R.. 2014. Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-28.
https://search.emarefa.net/detail/BIM-1040783
Modern Language Association (MLA)
Erkes, Dan A.& Selvan, Senthamil R.. Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity. Journal of Immunology Research No. 2014 (2014), pp.1-28.
https://search.emarefa.net/detail/BIM-1040783
American Medical Association (AMA)
Erkes, Dan A.& Selvan, Senthamil R.. Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-28.
https://search.emarefa.net/detail/BIM-1040783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040783