Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies
Joint Authors
Schulte-Pelkum, Johannes
Radice, Antonella
Norman, Gary L.
Lόpez Hoyos, Marcos
Lakos, Gabriella
Buchner, Carol
Miyara, Makoto
Stinton, Laura
Musset, Lucile
Mahler, Michael
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Antineutrophil cytoplasmic antibodies (ANCA) are the serological hallmark of some idiopathic systemic vasculitides.
Besides the investigation of ANCA-associated vasculitis (AAV) and constant effort for a standardized nomenclature and classification of the AAV, a main focus of research during the last few years has been to constantly improve the performance of enzyme immunoassays.
With the latest so called third generation ELISA, this goal seemed to be fulfilled.
The International Consensus Statement on Testing and Reporting of ANCA gave recommendations for standardized strategies for the serological diagnosis of ANCA.
New developments now target the system immanent drawbacks of the respective diagnostic methods, be it the need for batching and the long time to result for ELISA, or the high likelihood of error and subjectivity of indirect immunofluorescence (IIF).
Random access technology and multiplexing for solid phase assays as well as digital imaging for IIF are tools which may help to expedite and simplify routine diagnostics in the lab and in emergency settings.
Recent findings indicate that PR3-ANCA have clinical utility beyond the diagnosis of AAV.
PR3-ANCA can also serve as an aid for the differentiation between ulcerative colitis (UC) and Crohn’s disease (CrD) and the stratification of UC patients.
This review provides a detailed review of what is known about ANCA and highlights the latest research and state-of-the-art developments in this area.
American Psychological Association (APA)
Schulte-Pelkum, Johannes& Radice, Antonella& Norman, Gary L.& Lόpez Hoyos, Marcos& Lakos, Gabriella& Buchner, Carol…[et al.]. 2014. Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040785
Modern Language Association (MLA)
Schulte-Pelkum, Johannes…[et al.]. Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040785
American Medical Association (AMA)
Schulte-Pelkum, Johannes& Radice, Antonella& Norman, Gary L.& Lόpez Hoyos, Marcos& Lakos, Gabriella& Buchner, Carol…[et al.]. Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040785