Adoptive TIL Transfer in the Adjuvant Setting for Melanoma: Long-Term Patient Survival
Joint Authors
Khammari, A.
Knol, Anne-Chantal
Nguyen, Jean-Michel
Bossard, Céline
Denis, Marc-Guillaume
Pandolfino, Marie-Christine
Quéreux, Gaëlle
Bercegeay, Sylvain
Dreno, B.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Two first analyses of our clinical trial on TIL as adjuvant therapy for melanoma were published in 2002 and 2007.
We present here an update of the clinical results after a 17-year median followup.
In this trial, disease-free patients were randomly assigned to receive either TIL/IL-2 or IL-2.
The relapse-free survival (RFS) was the primary objective.
Eighty-eight patients were enrolled.
A new analysis performed in May 2013 did not show significant changes in RFS or OS duration.
However, our first finding on the association between the number of invaded lymph nodes and TIL effectiveness was strengthened.
The Cox model adjusted on this interaction showed for the first time a significant treatment effect when considering the overall population, both on the RFS and OS.
Patients treated with TIL had a longer RFS ( P = 0.023 ) or OS ( P = 0.020 ).
This study being with a very long followup (17 years), confirmed the association between TIL effectiveness and the number of invaded lymph nodes, indicating that a low tumor burden could be a crucial factor enhancing the curative effect of TIL in possible microscopic residual disease.
Moreover, we confirmed that a prolonged survival was associated with the presence of specific TIL and a decrease in Foxp3 expression.
American Psychological Association (APA)
Khammari, A.& Knol, Anne-Chantal& Nguyen, Jean-Michel& Bossard, Céline& Denis, Marc-Guillaume& Pandolfino, Marie-Christine…[et al.]. 2014. Adoptive TIL Transfer in the Adjuvant Setting for Melanoma: Long-Term Patient Survival. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040786
Modern Language Association (MLA)
Khammari, A.…[et al.]. Adoptive TIL Transfer in the Adjuvant Setting for Melanoma: Long-Term Patient Survival. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040786
American Medical Association (AMA)
Khammari, A.& Knol, Anne-Chantal& Nguyen, Jean-Michel& Bossard, Céline& Denis, Marc-Guillaume& Pandolfino, Marie-Christine…[et al.]. Adoptive TIL Transfer in the Adjuvant Setting for Melanoma: Long-Term Patient Survival. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040786