Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience
Joint Authors
Valotti, Monica
Sottini, Alessandra
Lanfranchi, Arnalda
Bolda, Federica
Serana, Federico
Bertoli, Diego
Giustini, Viviana
Vaglio Tessitore, Marion
Caimi, Luigi
Imberti, Luisa
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Levels of Kappa-deleting recombination excision circles (KRECs), T-cell receptor excision circles (TRECs), and T-cell repertoire diversity were evaluated in 1038 samples of 124 children with primary immunodeficiency, of whom 102 (54 with severe combined immunodeficiency and 48 with other types of immunodeficiency) underwent hematopoietic stem cell transplantation.
Twenty-two not transplanted patients with primary immunodeficiency were used as controls.
Only data of patients from whom at least five samples were sent to the clinical laboratory for routine monitoring of lymphocyte reconstitutions were included in the analysis.
The mean time of the follow-up was 8 years.
The long-lasting posttransplantation kinetics of KREC and TREC production occurred similarly in patients with severe combined immunodeficiency and with other types of immunodeficiency and, in both groups, the T-cell reconstitution was more efficient than in nontransplanted children.
Although thymic output decreased in older transplanted patients, the degree of T-cell repertoire diversity, after an initial increase, remained stable during the observation period.
However, the presence of graft-versus-host disease and ablative conditioning seemed to play a role in the time-related shaping of T-cell repertoire.
Overall, our data suggest that long-term B- and T-cell reconstitution was equally achieved in children with severe combined immunodeficiency and with other types of primary immunodeficiency.
American Psychological Association (APA)
Valotti, Monica& Sottini, Alessandra& Lanfranchi, Arnalda& Bolda, Federica& Serana, Federico& Bertoli, Diego…[et al.]. 2014. Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040800
Modern Language Association (MLA)
Valotti, Monica…[et al.]. Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040800
American Medical Association (AMA)
Valotti, Monica& Sottini, Alessandra& Lanfranchi, Arnalda& Bolda, Federica& Serana, Federico& Bertoli, Diego…[et al.]. Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040800