Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches
Joint Authors
Blasczyk, Rainer
Kunze-Schumacher, Heike
Bade-Doeding, Christina
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HLA class I incompatibilities still remain one of the main barriers for unrelated bone marrow transplantation (BMT); hence the molecular understanding of how to mismatch patients and donors and still have successful clinical outcomes will guide towards the future of unrelated BMT.
One way to estimate the magnitude of polymorphisms within the PBR is to determine which peptides can be selected by individual HLA alleles and subsequently presented for recognition by T cells.
The features (structure, length, and sequence) of different peptides each confer an individual pHLA landscape and thus directly shape the individual immune response.
The elution and sequencing of peptides by mass spectrometric analysis enable determining the bona fide repertoire of presented peptides for a given allele.
This is an effective and simple way to compare the functions of allelic variants and make a first assessment of their degree of permissivity.
We describe the methodology used for peptide sequencing and the limitations of peptide prediction tools compared to experimental methods.
We highlight the altered peptide features that are observed between allelic variants and the need to discover the altered peptide repertoire in situations of “artificial” graft versus host disease (GvHD) that occur in HLA-specific hypersensitive immune responses to drugs.
American Psychological Association (APA)
Kunze-Schumacher, Heike& Blasczyk, Rainer& Bade-Doeding, Christina. 2014. Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040802
Modern Language Association (MLA)
Kunze-Schumacher, Heike…[et al.]. Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040802
American Medical Association (AMA)
Kunze-Schumacher, Heike& Blasczyk, Rainer& Bade-Doeding, Christina. Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040802