Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma

Joint Authors

Han, Su-xia
Bai, E.
Jin, Gui-hua
He, Chen-chen
Guo, Xi-jing
Wang, Li-juan
Li, Meng
Ying, Xia
Zhu, Qing

Source

Journal of Immunology Research

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-04-22

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Purpose.

Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis.

Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ.

The role of these proteins in hepatocellular carcinoma (HCC) is unclear.

Methods.

The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining.

The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay.

Results.

YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients.

The expression of YAP was significantly correlated with Edmondson stage ( P > 0 .

05 ), serum AFP level ( P > 0 .

05 ), and HCC prognosis ( P > 0 .

05 ).

AREG expression was also significantly correlated with Edmondson stage ( P > 0 .

05 ) and serum AFP level ( P > 0 .

05 ).

In addition, the expression of serum AREG was higher than serum AFP in HCC patients.

Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients.

Conclusions.

YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC.

American Psychological Association (APA)

Han, Su-xia& Bai, E.& Jin, Gui-hua& He, Chen-chen& Guo, Xi-jing& Wang, Li-juan…[et al.]. 2014. Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040804

Modern Language Association (MLA)

Han, Su-xia…[et al.]. Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040804

American Medical Association (AMA)

Han, Su-xia& Bai, E.& Jin, Gui-hua& He, Chen-chen& Guo, Xi-jing& Wang, Li-juan…[et al.]. Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040804

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1040804