Activation Effects of Polysaccharides of Flammulina velutipes Mycorrhizae on the T Lymphocyte Immune Function

Abstract EN

Flammulina velutipes mycorrhizae have increasingly been produced with increasing of F.

velutipes production.

A mouse model was thus used to examine potential effect of F.

velutipes mycorrhizae on the immune function.

Fifty female Wistar mice (5-weeks-old) weighed 15–20 g were randomly allocated into five groups.

Polysaccharide of F.

velutipes mycorrhizae were treated with mice and mice spleen lymphocytes.

The levels of CD3+, CD4+, and CD8+ T lymphocyte, interleukin-2 (IL-2), and tumor necrosis factor-a (TNF- α ) were determined.

The results showed that the proportions of CD3+, and CD4+ T lymphocyte, the ratio of CD4+/CD8+, and the levels of IL-2 and TNF-a were significantly increased in polysaccharide of F.

velutipes mycorrhizae, while the proportion of CD8+ T lymphocyte was decreased in polysaccharide of F.

velutipes mycorrhizae-dose dependent manner.

Our findings indicated that a long term exposure of polysaccharide of F.

velutipes mycorrhizae could activate the T lymphocyte immune function.

Polysaccharide of F.

velutipes mycorrhizae was expected to develop into the immune health products.