Selective Depletion of Regulatory T Cell Subsets by Docetaxel Treatment in Patients with Nonsmall Cell Lung Cancer
Joint Authors
Zhang, Bin
Zhang, Yi
Li, Jie-Yao
Duan, Xiu-Fang
Wang, Li-Ping
Xu, Yu-Jie
Huang, Lan
Zhang, Teng-Fei
Liu, Jin-Yan
Li, Feng
Zhang, Zhen
Yue, Dong-Li
Wang, Fei
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Regulatory T (Treg) cells are potent suppressors that maintain immune homeostasis.
Accumulation of Treg can inhibit effective immune responses in cancer patients, leading to tumor development and progression.
Despite direct cytotoxicity, several chemotherapeutic drugs have been reported to deplete Treg cells for better prognosis for cancer patients.
Treg cells are a heterogenous population with at least three different subsets, nonsuppressive, resting, and activated Treg cells.
However, the characteristics of Treg cell subsets in lung cancer patients and how chemotherapy affects Treg cells remain elusive.
In this study, we first analyzed Treg cell subsets in peripheral blood samples from 40 nonsmall cell lung cancer (NSCLC) patients and 20 healthy donors.
Treg cells, specifically activated Treg cell subset, significantly increased in patients with NSCLC.
Compared to nonsuppressive Treg cells, activated Treg cells expressed higher level of CD39 and predominantly produced inhibitory cytokines.
In vitro assay showed that docetaxel reduced all three subsets of Treg cells.
More importantly, we found docetaxel-based chemotherapy significantly decreased all three Treg subsets after 4 cycles of treatment in 17 NSCLC patients.
Taken together, this study revealed dynamic changes of various Treg cell subsets in NSCLC patients before and after chemotherapy, providing activated Treg cells as a potential target for chemotherapy.
American Psychological Association (APA)
Li, Jie-Yao& Duan, Xiu-Fang& Wang, Li-Ping& Xu, Yu-Jie& Huang, Lan& Zhang, Teng-Fei…[et al.]. 2014. Selective Depletion of Regulatory T Cell Subsets by Docetaxel Treatment in Patients with Nonsmall Cell Lung Cancer. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040824
Modern Language Association (MLA)
Li, Jie-Yao…[et al.]. Selective Depletion of Regulatory T Cell Subsets by Docetaxel Treatment in Patients with Nonsmall Cell Lung Cancer. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040824
American Medical Association (AMA)
Li, Jie-Yao& Duan, Xiu-Fang& Wang, Li-Ping& Xu, Yu-Jie& Huang, Lan& Zhang, Teng-Fei…[et al.]. Selective Depletion of Regulatory T Cell Subsets by Docetaxel Treatment in Patients with Nonsmall Cell Lung Cancer. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040824