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Anti-MDA5 Antibodies in a Large Mediterranean Population of Adults with Dermatomyositis
Joint Authors
Labrador-Horrillo, Moises
Martinez, Maria Angeles
Selva-O'Callaghan, Albert
Trallero-Araguas, Ernesto
Balada, Eva
Vilardell-Tarres, Miquel
Juárez-Rubio, Cándido
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A new myositis-specific autoantibody directed against melanoma differentiation-associated gene 5 (anti-MDA5) has been described in patients with dermatomyositis (DM).
We report the clinical characteristics of patients with anti-MDA5 in a large Mediterranean cohort of DM patients from a single center, and analyze the feasibility of detecting this autoantibody in patient sera using new assays with commercially available recombinant MDA5.
The study included 117 white adult patients with DM, 15 (13%) of them classified as clinically amyopathic dermatomyositis (CADM).
Clinical manifestations were analyzed, with special focus on interstitial lung disease and its severity.
Determination of anti-MDA5 antibodies was performed by a new ELISA and immunoblot technique.
In sera, from 14 (12%) DM patients (8 CADM), MDA5 was recognized by ELISA, and confirmed by immunoblot.
Eight of the 14 anti-MDA5-positive patients (57.14%) presented rapidly-progressive interstitial lung disease (RP-ILD) versus 3 of 103 anti-MDA5-negative patients (2.91%) (P<0.05; OR: 44.4, 95% CI 9.3–212).
The cumulative survival rate was significantly lower in anti-MDA5-positive patients than in the remainder of the series (P<0.05).
Patients with anti-MDA5-associated ILD presented significantly lower 70-month cumulative survival than antisynthetase-associated ILD patients.
Among the cutaneous manifestations, only panniculitis was significantly associated with the presence of anti-MDA5 antibodies (P<0.05; OR: 3.85, 95% CI 1.11–13.27).
These findings support the reliability of using commercially available recombinant MDA5 for detecting anti-MDA5 antibodies and confirm the association of these antibodies with RP-ILD in a large series of Mediterranean patients with DM.
American Psychological Association (APA)
Labrador-Horrillo, Moises& Martinez, Maria Angeles& Selva-O'Callaghan, Albert& Trallero-Araguas, Ernesto& Balada, Eva& Vilardell-Tarres, Miquel…[et al.]. 2014. Anti-MDA5 Antibodies in a Large Mediterranean Population of Adults with Dermatomyositis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040825
Modern Language Association (MLA)
Labrador-Horrillo, Moises…[et al.]. Anti-MDA5 Antibodies in a Large Mediterranean Population of Adults with Dermatomyositis. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040825
American Medical Association (AMA)
Labrador-Horrillo, Moises& Martinez, Maria Angeles& Selva-O'Callaghan, Albert& Trallero-Araguas, Ernesto& Balada, Eva& Vilardell-Tarres, Miquel…[et al.]. Anti-MDA5 Antibodies in a Large Mediterranean Population of Adults with Dermatomyositis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040825