Immunomodulatory Properties of HLA-G in Infectious Diseases
Joint Authors
Amiot, Laurence
Vu, Nicolas
Samson, Michel
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts.
Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions.
The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases.
The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control.
In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent.
The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections.
We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G.
New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.
American Psychological Association (APA)
Amiot, Laurence& Vu, Nicolas& Samson, Michel. 2014. Immunomodulatory Properties of HLA-G in Infectious Diseases. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040829
Modern Language Association (MLA)
Amiot, Laurence…[et al.]. Immunomodulatory Properties of HLA-G in Infectious Diseases. Journal of Immunology Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040829
American Medical Association (AMA)
Amiot, Laurence& Vu, Nicolas& Samson, Michel. Immunomodulatory Properties of HLA-G in Infectious Diseases. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040829