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Current Concepts and Future Directions for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies
Joint Authors
Fritzler, Marvin J.
Meroni, Pier-Luigi
Mahler, Michael
Bossuyt, Xavier
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The detection of autoantibodies that target intracellular antigens, commonly termed anti-nuclear antibodies (ANA), is a serological hallmark in the diagnosis of systemic autoimmune rheumatic diseases (SARD).
Different methods are available for detection of ANA and all bearing their own advantages and limitations.
Most laboratories use the indirect immunofluorescence (IIF) assay based on HEp-2 cell substrates.
Due to the subjectivity of this diagnostic platform, automated digital reading systems have been developed during the last decade.
In addition, solid phase immunoassays using well characterized antigens have gained widespread adoption in high throughput laboratories due to their ease of use and open automation.
Despite all the advances in the field of ANA detection and its contribution to the diagnosis of SARD, significant challenges persist.
This review provides a comprehensive overview of the current status on ANA testing including automated IIF reading systems and solid phase assays and suggests an approach to interpretation of results and discusses meeting the problems of assay standardization and other persistent challenges.
American Psychological Association (APA)
Mahler, Michael& Meroni, Pier-Luigi& Bossuyt, Xavier& Fritzler, Marvin J.. 2014. Current Concepts and Future Directions for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1040835
Modern Language Association (MLA)
Mahler, Michael…[et al.]. Current Concepts and Future Directions for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies. Journal of Immunology Research No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1040835
American Medical Association (AMA)
Mahler, Michael& Meroni, Pier-Luigi& Bossuyt, Xavier& Fritzler, Marvin J.. Current Concepts and Future Directions for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1040835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040835