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The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6IL-10 Axis and Is Associated with the Parasite Load
Joint Authors
Guimarães da Costa, Allyson
do Valle Antonelli, Lis Ribeiro
Augusto Carvalho Costa, Pedro
Paulo Diniz Pimentel, João
Garcia, Nadja Pinto
Monteiro Tarragô, Andréa
Socorro Lopes dos Santos, Maria do Perpétuo
Hekcmann, Maria Izabel Ovellar
Sadahiro, Aya
Teixeira-Carvalho, Andréa
Malheiro, Adriana
Martins-Filho, Olindo Assis
Nogueira, Paulo Afonso
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Recent studies have shown that the inflammatory process, including the biomarker production, and the intense activation of innate immune responses are greater in the malaria caused by Plasmodium vivax than other species.
Here, we examined the levels of serum biomarkers and their interaction during acute malaria.
Material and Methods.
Blood samples were collected from P.
vivax-infected patients at admission and from healthy donors.
Levels of serum biomarkers were measured by Cytometric Bead Assay or ELISA.
Results.
P.
vivax infection triggered the production of both inflammatory and regulatory biomarkers.
Levels of IL-6, CXCL-8, IFN-γ, IL-5, and IL-10 were higher in P.
vivax-infected patients than in healthy donors.
On the other hand, malaria patients produced lower levels of TNF-α, IL-12p70, and IL-2 than healthy individuals.
While the levels of IL-10 and IL-6 were found independent on the number of malaria episodes, higher levels of these cytokines were seen in patients with higher parasite load.
Conclusion.
A mixed pattern of proinflammatory and regulatory biomarkers is produced in P.
vivax malaria.
Analysis of biomarker network suggests that IL-10 and IL-6 are a robust axis in malaria patients and that this interaction seems to be associated with the parasite load.
American Psychological Association (APA)
Guimarães da Costa, Allyson& do Valle Antonelli, Lis Ribeiro& Augusto Carvalho Costa, Pedro& Paulo Diniz Pimentel, João& Garcia, Nadja Pinto& Monteiro Tarragô, Andréa…[et al.]. 2014. The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6IL-10 Axis and Is Associated with the Parasite Load. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040837
Modern Language Association (MLA)
Guimarães da Costa, Allyson…[et al.]. The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6IL-10 Axis and Is Associated with the Parasite Load. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040837
American Medical Association (AMA)
Guimarães da Costa, Allyson& do Valle Antonelli, Lis Ribeiro& Augusto Carvalho Costa, Pedro& Paulo Diniz Pimentel, João& Garcia, Nadja Pinto& Monteiro Tarragô, Andréa…[et al.]. The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6IL-10 Axis and Is Associated with the Parasite Load. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040837