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Acquired Hemophilia A: A Frequently Overlooked Autoimmune Hemorrhagic Disorder
Joint Authors
Sakurai, Yoshihiko
Takeda, Tomohiro
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acquired hemophilia A (AHA) is a rare hemorrhagic disease in which autoantibodies against coagulation factor VIII- (FVIII-) neutralizing antibodies (inhibitors) impair the intrinsic coagulation system.
As the inhibitors developed in AHA are autoantibodies, the disease may have an autoimmune cause and is often associated with autoimmune disease.
Although acute hemorrhage associated with AHA may be fatal and is costly to treat, AHA is often unrecognized or misdiagnosed.
AHA should thus be considered in the differential diagnosis particularly in postpartum women and the elderly with bleeding tendency or prolonged activated partial thromboplastin time.
Cross-mixing tests and measurement of FVIII-binding antibodies are useful to confirm AHA diagnosis.
For treatment of acute hemorrhage, hemostatic therapy with bypassing agents should be provided.
Unlike in congenital hemophilia A with inhibitors, in which immune tolerance induction therapy using repetitive infusions of high-dose FVIII concentrates is effective for inhibitor eradication, immune tolerance induction therapy has shown poor efficacy in treating AHA.
Immunosuppressive treatment should thus be initiated to eradicate inhibitors as soon as the diagnosis of AHA is confirmed.
American Psychological Association (APA)
Sakurai, Yoshihiko& Takeda, Tomohiro. 2014. Acquired Hemophilia A: A Frequently Overlooked Autoimmune Hemorrhagic Disorder. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040839
Modern Language Association (MLA)
Sakurai, Yoshihiko& Takeda, Tomohiro. Acquired Hemophilia A: A Frequently Overlooked Autoimmune Hemorrhagic Disorder. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040839
American Medical Association (AMA)
Sakurai, Yoshihiko& Takeda, Tomohiro. Acquired Hemophilia A: A Frequently Overlooked Autoimmune Hemorrhagic Disorder. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040839