Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62IMP2 in Ovarian Cancer
Joint Authors
Liu, Xinxin
Ye, Hua
Li, Liuxia
Li, Wenjie
Zhang, Yi
Zhang, Jian-Ying
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ovarian cancer is one of the leading causes of cancer-related deaths among women.
There is an urgent need of better approaches for the identification of appropriate biomarkers in the early detection of ovarian cancer.
The aim of this study was to elucidate the significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins (IMPs) in patients with ovarian cancer.
In this study, autoantibody responses to two members (IMP1 and p62/IMP2) of IMPs were evaluated by enzyme-linked immunosorbent assay (ELISA), western blotting, and indirect immunofluorescence assay in sera from patients with ovarian cancer and normal human individuals.
The results have demonstrated that both IMP1 and p62/IMP2 can induce relatively higher frequency of autoantibody responses in patients with ovarian cancer (26.5% and 29.4%) compared to normal individuals (P<0.01).
Our preliminary data suggest that IMP1 and p62/IMP2 can stimulate autoimmune responses in ovarian cancer, and anti-IMP1 and anti-p62/IMP2 autoantibodies could be used as potential biomarkers in immunodiagnosis of ovarian cancer.
American Psychological Association (APA)
Liu, Xinxin& Ye, Hua& Li, Liuxia& Li, Wenjie& Zhang, Yi& Zhang, Jian-Ying. 2014. Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62IMP2 in Ovarian Cancer. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040842
Modern Language Association (MLA)
Liu, Xinxin…[et al.]. Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62IMP2 in Ovarian Cancer. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040842
American Medical Association (AMA)
Liu, Xinxin& Ye, Hua& Li, Liuxia& Li, Wenjie& Zhang, Yi& Zhang, Jian-Ying. Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62IMP2 in Ovarian Cancer. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040842