Adipokines, Metabolic Syndrome and Rheumatic Diseases
Joint Authors
Conde, Javier
Pino, Jesús
Abella, Vanessa
Lazzaro, Verónica
Gómez-Reino, Juan J.
Scotece, Morena
Gualillo, Oreste
Lopez, Veronica
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The metabolic syndrome (MetS) is a cluster of cardiometabolic disorders that result from the increasing prevalence of obesity.
The major components of MetS include insulin resistance, central obesity, dyslipidemia, and hypertension.
MetS identifies the central obesity with increased risk for cardiovascular diseases (CVDs) and type-2 diabetes mellitus (T2DM).
Patients with rheumatic diseases, such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis, have increased prevalence of CVDs.
Moreover, CVD risk is increased when obesity is present in these patients.
However, traditional cardiovascular risk factors do not completely explain the enhanced cardiovascular risk in this population.
Thus, MetS and the altered secretion patterns of proinflammatory adipokines present in obesity could be the link between CVDs and rheumatic diseases.
Furthermore, adipokines have been linked to the pathogenesis of MetS and its comorbidities through their effects on vascular function and inflammation.
In the present paper, we review recent evidence of the role played by adipokines in the modulation of MetS in the general population, and in patients with rheumatic diseases.
American Psychological Association (APA)
Abella, Vanessa& Scotece, Morena& Conde, Javier& Lopez, Veronica& Lazzaro, Verónica& Pino, Jesús…[et al.]. 2014. Adipokines, Metabolic Syndrome and Rheumatic Diseases. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040846
Modern Language Association (MLA)
Abella, Vanessa…[et al.]. Adipokines, Metabolic Syndrome and Rheumatic Diseases. Journal of Immunology Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040846
American Medical Association (AMA)
Abella, Vanessa& Scotece, Morena& Conde, Javier& Lopez, Veronica& Lazzaro, Verónica& Pino, Jesús…[et al.]. Adipokines, Metabolic Syndrome and Rheumatic Diseases. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040846