HLA-E: A Novel Player for Histocompatibility
Joint Authors
Blasczyk, Rainer
Bade-Doeding, Christina
Kraemer, Thomas
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The classical class I human leukocyte antigens (HLA-A, -B, and -C) present allele-specific self- or pathogenic peptides originated by intracellular processing to CD8+ immune effector cells.
Even a single mismatch in the heavy chain (hc) of an HLA class I molecule can impact on the peptide binding profile.
Since HLA class I molecules are highly polymorphic and most of their polymorphisms affect the peptide binding region (PBR), it becomes obvious that systematic HLA matching is crucial in determining the outcome of transplantation.
The opposite holds true for the nonclassical HLA class I molecule HLA-E.
HLA-E polymorphism is restricted to two functional versions and is thought to present a limited set of highly conserved peptides derived from class I leader sequences.
However, HLA-E appears to be a ligand for the innate and adaptive immune system, where the immunological response to peptide-HLA-E complexes is dictated through the sequence of the bound peptide.
Structural investigations clearly demonstrate how subtle amino acid differences impact the strength and response of the cognate CD94/NKG2 or T cell receptor.
American Psychological Association (APA)
Kraemer, Thomas& Blasczyk, Rainer& Bade-Doeding, Christina. 2014. HLA-E: A Novel Player for Histocompatibility. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040848
Modern Language Association (MLA)
Kraemer, Thomas…[et al.]. HLA-E: A Novel Player for Histocompatibility. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040848
American Medical Association (AMA)
Kraemer, Thomas& Blasczyk, Rainer& Bade-Doeding, Christina. HLA-E: A Novel Player for Histocompatibility. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040848