The Dual Role of HLA-G in Cancer
Joint Authors
Moreau, Philippe
Carosella, Edgardo D.
Rouas-Freiss, Nathalie
LeMaoult, Joel
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies.
For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been proposed to counteract it.
Aside from these numerous studies on solid tumors, recent data showed that HLA-G inhibits the proliferation of malignant B cells due to the interaction between HLA-G and its receptor ILT2, which mediates negative signaling on B cell proliferation.
These results led to the conjecture that, according to the malignant cell type, HLA-G should be blocked or conversely induced to counteract tumor progression.
In this context, we will here present (i) the dual role of HLA-G in solid and liquid tumors with special emphasis on (ii) the HLA-G active structures and their related ILT2 and ILT4 receptors and (iii) the current knowledge on regulatory mechanisms of HLA-G expression in tumors.
American Psychological Association (APA)
Rouas-Freiss, Nathalie& Moreau, Philippe& LeMaoult, Joel& Carosella, Edgardo D.. 2014. The Dual Role of HLA-G in Cancer. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040849
Modern Language Association (MLA)
Rouas-Freiss, Nathalie…[et al.]. The Dual Role of HLA-G in Cancer. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040849
American Medical Association (AMA)
Rouas-Freiss, Nathalie& Moreau, Philippe& LeMaoult, Joel& Carosella, Edgardo D.. The Dual Role of HLA-G in Cancer. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040849