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In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis
Joint Authors
Di Gioacchino, Mario
Poma, Anna
Ragnelli, Anna Maria
de Lapuente, Joaquin
Ramos, David
Borras, Miquel
Aimola, Pierpaolo
Santucci, Sandro
De Marzi, Laura
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications.
In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs.
Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations.
TEM analysis showed the presence of NPs in alveolar macrophages.
Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation).
American Psychological Association (APA)
Poma, Anna& Ragnelli, Anna Maria& de Lapuente, Joaquin& Ramos, David& Borras, Miquel& Aimola, Pierpaolo…[et al.]. 2014. In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040850
Modern Language Association (MLA)
Poma, Anna…[et al.]. In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis. Journal of Immunology Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040850
American Medical Association (AMA)
Poma, Anna& Ragnelli, Anna Maria& de Lapuente, Joaquin& Ramos, David& Borras, Miquel& Aimola, Pierpaolo…[et al.]. In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040850