Expression of TNF-α, April and BCMA in Behcet’s Disease
Joint Authors
Shaker, Olfat G.
Ghallab, Noha A.
Tawfic, Shereen O.
El-Tawdy, Amira M.
El-Komy, Mohamed H. M.
El Menyawi, Manal
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet’s disease (BD).
B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family.
BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells.
Objective.
Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD.
Patients and Methods.
This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD.
Twenty age-matched healthy male volunteers served as control.
Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques.
Results.
The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner ( P < 0.001 ) .
Positive correlation was observed between hs-CRP and BDCAF (Behcet’s disease current activity forum) index (r 0.68, P < 0.001 ) .
None of the TNF family members tested was affected by a positive pathergy test.
Conclusions.
Patients have significantly higher levels of TNF family members’ (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.
American Psychological Association (APA)
Shaker, Olfat G.& Tawfic, Shereen O.& El-Tawdy, Amira M.& El-Komy, Mohamed H. M.& El Menyawi, Manal& Ghallab, Noha A.. 2014. Expression of TNF-α, April and BCMA in Behcet’s Disease. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040854
Modern Language Association (MLA)
Shaker, Olfat G.…[et al.]. Expression of TNF-α, April and BCMA in Behcet’s Disease. Journal of Immunology Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040854
American Medical Association (AMA)
Shaker, Olfat G.& Tawfic, Shereen O.& El-Tawdy, Amira M.& El-Komy, Mohamed H. M.& El Menyawi, Manal& Ghallab, Noha A.. Expression of TNF-α, April and BCMA in Behcet’s Disease. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040854