The Secretion of IL-22 from Mucosal NKp44+ NK Cells Is Associated with Microbial Translocation and Virus Infection in SIVSHIV-Infected Chinese Macaques
Joint Authors
Wang, Wei
Wu, Fangxin
Cong, Zhe
Liu, Kejian
Wei, Qiang
Qin, Chuan
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Microbial translocation (MT) causes systemic immune activation in chronic human immunodeficiency virus (HIV) infection.
The role of a novel subtype of innate lymphoid cells, the NKp44+ NK cells, in HIV/simian immunodeficiency virus- (SIV-) induced MT remains unknown.
In this study, 12 simian-human immunodeficiency virus- (SHIV-) infected macaques were chosen and split into two groups based on the MT level.
Blood and Peripheral lymphoid tissue were sampled for flow cytometric analysis, viral load detection, and interleukin testing.
Then, six naive Chinese macaques were used to determine the dynamics of cytokine secretion from mucosal NKp44+ NK cells in different phases of SIV infection.
As a result, the degranulation capacity and IL-22 production of mucosal NKp44+ NK cells were associated with the MT level in the SHIV-infected macaques.
And the number of mucosal NKp44+ NK cells and IL-22 secretion by these cells were lower in the chronic phase than in the early acute phase of SIV infection.
The number of mucosal NKp44+ NK cells and interleukin-22 (IL-22) secretion by these cells increased before MT occurred.
Therefore, we conclude that a decline in IL-22 production from mucosal NKp44+ NK cells induced by virus infection may be one of the causes of microbial translocation in HIV/SIV infection.
American Psychological Association (APA)
Wang, Wei& Wu, Fangxin& Cong, Zhe& Liu, Kejian& Qin, Chuan& Wei, Qiang. 2014. The Secretion of IL-22 from Mucosal NKp44+ NK Cells Is Associated with Microbial Translocation and Virus Infection in SIVSHIV-Infected Chinese Macaques. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040856
Modern Language Association (MLA)
Wang, Wei…[et al.]. The Secretion of IL-22 from Mucosal NKp44+ NK Cells Is Associated with Microbial Translocation and Virus Infection in SIVSHIV-Infected Chinese Macaques. Journal of Immunology Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040856
American Medical Association (AMA)
Wang, Wei& Wu, Fangxin& Cong, Zhe& Liu, Kejian& Qin, Chuan& Wei, Qiang. The Secretion of IL-22 from Mucosal NKp44+ NK Cells Is Associated with Microbial Translocation and Virus Infection in SIVSHIV-Infected Chinese Macaques. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040856