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The Pathology of T Cells in Systemic Lupus Erythematosus
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies.
Thus, the condition was traditionally classified as a “B-cell disease”.
Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed difficult for the “helpless” B cells to become functional enough to trigger SLE-related inflammation.
T cells have been recognized to be crucial in the pathogenicity of SLE through their capabilities to communicate with and offer enormous help to B cells for driving autoantibody production.
Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells.
Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed.
Additionally, how regulatory CD4+, CD8+, and γδ T cells tune down lupus-related inflammation will be highlighted.
Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings.
American Psychological Association (APA)
Mak, Anselm& Kow, Nien Yee. 2014. The Pathology of T Cells in Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040867
Modern Language Association (MLA)
Mak, Anselm& Kow, Nien Yee. The Pathology of T Cells in Systemic Lupus Erythematosus. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040867
American Medical Association (AMA)
Mak, Anselm& Kow, Nien Yee. The Pathology of T Cells in Systemic Lupus Erythematosus. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040867