The Pathology of T Cells in Systemic Lupus Erythematosus

Joint Authors

Mak, Anselm
Kow, Nien Yee

Source

Journal of Immunology Research

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-04-23

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Biology

Abstract EN

Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies.

Thus, the condition was traditionally classified as a “B-cell disease”.

Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed difficult for the “helpless” B cells to become functional enough to trigger SLE-related inflammation.

T cells have been recognized to be crucial in the pathogenicity of SLE through their capabilities to communicate with and offer enormous help to B cells for driving autoantibody production.

Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells.

Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed.

Additionally, how regulatory CD4+, CD8+, and γδ T cells tune down lupus-related inflammation will be highlighted.

Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings.

American Psychological Association (APA)

Mak, Anselm& Kow, Nien Yee. 2014. The Pathology of T Cells in Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040867

Modern Language Association (MLA)

Mak, Anselm& Kow, Nien Yee. The Pathology of T Cells in Systemic Lupus Erythematosus. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040867

American Medical Association (AMA)

Mak, Anselm& Kow, Nien Yee. The Pathology of T Cells in Systemic Lupus Erythematosus. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040867

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1040867