The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
Joint Authors
Guimarães da Costa, Allyson
Malheiro, Adriana
Espir, Thaís Tibery
Figueira, Luanda de Paula
Naiff, Maricleide de Farias
Franco, Antonia Maria Ramos
Ramalho-Ortigao, Marcelo
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil.
A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis.
The isolates were identified as Leishmania guyanensis, L.
naiffi, and L.
amazonensis.
Most (64%) of the patients were male ranging in age from 18 to 58 years.
Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species.
Infection caused by L.
guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L.
amazonensis.
Patients with infection caused by L.
naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed.
American Psychological Association (APA)
Espir, Thaís Tibery& Figueira, Luanda de Paula& Naiff, Maricleide de Farias& Guimarães da Costa, Allyson& Ramalho-Ortigao, Marcelo& Malheiro, Adriana…[et al.]. 2014. The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040877
Modern Language Association (MLA)
Espir, Thaís Tibery…[et al.]. The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040877
American Medical Association (AMA)
Espir, Thaís Tibery& Figueira, Luanda de Paula& Naiff, Maricleide de Farias& Guimarães da Costa, Allyson& Ramalho-Ortigao, Marcelo& Malheiro, Adriana…[et al.]. The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040877