Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1

Abstract EN

Early diagnosis and prognosis monitoring are very important for the survival of patients with bladder cancer.

To identify candidate biomarkers of bladder cancer, we used a combination of techniques including 2-DE, co-IP, western blot, LC-MS/MS, and immunohistochemistry.

Hsp74 was identified with high expression in bladder cancer.

The cellular location of expression products of gene Hsp74 showed that they were distributed into cytoplasm and keratin 1 was found to be associated with Hsp74.

The results provide a new idea to understand the molecular basis of bladder cancer progression and pinpoint new potential molecular target for early diagnosis and therapeutic monitoring of bladder cancer.