Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice
Joint Authors
Ruan, Guang-ping
Yao, Xiang
Yang, Shuang-juan
Wang, Jin-xiang
Shu, Fan
Li, Zi-an
Liu, Ju-fen
Pang, Rong-qing
Pan, Xing-hua
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies.
No effective treatment for SLE currently exists.
Methods.
We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice.
Results.
After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls.
The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.
Conclusions.
The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
American Psychological Association (APA)
Ruan, Guang-ping& Yao, Xiang& Yang, Shuang-juan& Wang, Jin-xiang& Shu, Fan& Li, Zi-an…[et al.]. 2014. Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040888
Modern Language Association (MLA)
Ruan, Guang-ping…[et al.]. Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice. Journal of Immunology Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040888
American Medical Association (AMA)
Ruan, Guang-ping& Yao, Xiang& Yang, Shuang-juan& Wang, Jin-xiang& Shu, Fan& Li, Zi-an…[et al.]. Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040888