Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis
Joint Authors
Cardona-Muñoz, Ernesto German
Fajardo-Robledo, Nicte Selene
Nava, Arnulfo
Ponce-Guarneros, Manuel
Zavaleta-Muñiz, Soraya Amali
Salazar-Paramo, Mario
Flores-Chavez, Alejandra
Garcia-Cobian, Teresa
Gonzalez-Lopez, Laura
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA).
Ninety-five patients had ExRA and 130 had no ExRA.
There was no association of anti-CCP and anti-MCV levels with the presence of ExRA as total group ( P = 0.40 and P = 0.91 , resp.).
Making an analysis of individual manifestations, rheumatoid nodules were associated with positivity for rheumatoid factor (RF); ( P = 0.01 ), anti-CCP ( P = 0.048 ), and anti-MCV ( P = 0.02 ).
Instead, RF, anti-CCP, or anti-MCV were not associated with SS, chronic anemia, or peripheral neuropathy.
Levels of anti-CCP correlated with the score of the Health Assessment Questionnaire-Disability Index (HAQ-Di) ( r = 0.154 , P = 0.03 ), erythrocyte sedimentation rate (ESR); ( r = 0.155 , P = 0.03 ), and RF ( P = 0.254 , P < 0.001 ), whereas anti-MCV titres only correlated with RF ( r = 0.169 , P = 0.02 ).
On adjusted analysis, ExRA was associated with longer age ( P = 0.015 ), longer disease duration ( P = 0.007 ), higher DAS-28 score ( P = 0.002 ), and higher HAQ-DI score ( P = 0.007 ), but serum levels of anti-CCP and anti-MCV were not associated.
These findings show the need to strengthen the evaluation of the pathogenic mechanisms implied in each specific ExRA manifestation.
American Psychological Association (APA)
Gonzalez-Lopez, Laura& Rocha-Muñoz, Alberto Daniel& Ponce-Guarneros, Manuel& Flores-Chavez, Alejandra& Salazar-Paramo, Mario& Nava, Arnulfo…[et al.]. 2014. Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040889
Modern Language Association (MLA)
Gonzalez-Lopez, Laura…[et al.]. Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040889
American Medical Association (AMA)
Gonzalez-Lopez, Laura& Rocha-Muñoz, Alberto Daniel& Ponce-Guarneros, Manuel& Flores-Chavez, Alejandra& Salazar-Paramo, Mario& Nava, Arnulfo…[et al.]. Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040889