HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review
Joint Authors
Chung, Wen-Hung
Su, Shih-Chi
Cheng, Chi-Yuan
Chen, Chi-Hua
Chen, Wei-Li
Deng, Shin-Tarng
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions.
Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs).
Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity.
This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.
American Psychological Association (APA)
Cheng, Chi-Yuan& Su, Shih-Chi& Chen, Chi-Hua& Chen, Wei-Li& Deng, Shin-Tarng& Chung, Wen-Hung. 2014. HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040895
Modern Language Association (MLA)
Cheng, Chi-Yuan…[et al.]. HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040895
American Medical Association (AMA)
Cheng, Chi-Yuan& Su, Shih-Chi& Chen, Chi-Hua& Chen, Wei-Li& Deng, Shin-Tarng& Chung, Wen-Hung. HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040895