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Capillary Dilation and Rarefaction Are Correlated with Intracapillary Inflammation in Antibody-Mediated Rejection
Joint Authors
Li, Xue
Xie, Kenan
Chen, Jinsong
Liu, Zhihong
Sun, Qiquan
Zhang, Mingchao
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Antibody-mediated rejection (ABMR) remains one of the major causes of graft loss after renal transplantation.
It is dominated by endothelial damage in microcirculation.
Clarifying the mechanism of microcirculating damage is obviously a key step to understand the pathogenesis of ABMR.
Here we characterized capillary variation in ABMR and its possible mechanisms.
Compared with T cell-mediated rejection and stable grafts, there was a significant dilation and rarefaction in peritubular capillaries (PTCs) of the ABMR group; Image-Pro Plus revealed a significantly larger intra-PTC area.
Interestingly, the dilation of PTCs was strongly correlated with the intra-PTC cell counting.
Moreover, peritubular capillary inflammation is correlated with in situ T-bet expression, and there was a good correlation between the intra-PTC expression of T-bet and the PTC diameter.
HIF-1α up-regulation could be observed in ABMR but it was not necessary for capillary dilation.
In general, ABMR is characterized with early capillary dilation and rarefaction; our data confirmed that the dilation is strongly correlated with intracapillary inflammation, which in turn is correlated with in situ T-bet expression.
T-bet plays an important role in the development of microcirculating injury, and thus it is a potential target for the treatment of ABMR.
American Psychological Association (APA)
Li, Xue& Sun, Qiquan& Zhang, Mingchao& Xie, Kenan& Chen, Jinsong& Liu, Zhihong. 2014. Capillary Dilation and Rarefaction Are Correlated with Intracapillary Inflammation in Antibody-Mediated Rejection. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040914
Modern Language Association (MLA)
Li, Xue…[et al.]. Capillary Dilation and Rarefaction Are Correlated with Intracapillary Inflammation in Antibody-Mediated Rejection. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040914
American Medical Association (AMA)
Li, Xue& Sun, Qiquan& Zhang, Mingchao& Xie, Kenan& Chen, Jinsong& Liu, Zhihong. Capillary Dilation and Rarefaction Are Correlated with Intracapillary Inflammation in Antibody-Mediated Rejection. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040914