Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells
Joint Authors
Valentini, Mariagrazia
Piermattei, Alessia
Di Sante, Gabriele
Migliara, Giuseppe
Ria, Francesco
Delogu, Giovanni
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A close relationship exists between gut microbiota and immune responses.
An imbalance of this relationship can determine local and systemic immune diseases.
In fact the immune system plays an essential role in maintaining the homeostasis with the microbiota that normally resides in the gut, while, at the same time, the gut microbiota influences the immune system, modulating number and function of effector and regulatory T cells.
To achieve this aim, mutual regulation between immune system and microbiota is achieved through several mechanisms, including the engagement of toll-like receptors (TLRs), pathogen-specific receptors expressed on numerous cell types.
TLRs are able to recognize ligands from commensal or pathogen microbiota to maintain the tolerance or trigger the immune response.
In this review, we summarize the latest evidences about the role of TLRs expressed in adaptive T cells, to understand how the immune system promotes intestinal homeostasis, fights invasion by pathogens, and is modulated by the intestinal microbiota.
American Psychological Association (APA)
Valentini, Mariagrazia& Piermattei, Alessia& Di Sante, Gabriele& Migliara, Giuseppe& Delogu, Giovanni& Ria, Francesco. 2014. Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040915
Modern Language Association (MLA)
Valentini, Mariagrazia…[et al.]. Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040915
American Medical Association (AMA)
Valentini, Mariagrazia& Piermattei, Alessia& Di Sante, Gabriele& Migliara, Giuseppe& Delogu, Giovanni& Ria, Francesco. Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040915