Tumor-Activated T C R γ δ + T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of T C R α β + T Cells via Their Antigen-Presenting Cell-Like Effects
Joint Authors
Wang, Shengjun
Mao, Chaoming
Mou, Xiao
Zhou, Yuepeng
Yuan, Guoyue
Xu, Chengcheng
Liu, Hongli
Zheng, Tingting
Chen, Deyu
Tong, Jia
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human γδ T cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity.
However, it is not clear whether γδ T cells perform APC-like functions under pathological conditions.
In this study, we showed that, in contrast to peripheral-derived γδ T cells directly isolated from PBMCs of gastric cancer patients, tumor-activated γδ T cells not only killed tumor cells efficiently but also strongly induced primary CD4+ and CD8+ αβ T cells proliferation and differentiation.
More importantly, they abrogated the immunosuppression induced by CD4+CD25+ Treg cells and induced the cytotoxic function of CD8+ αβ T cells from patients with gastric cancer.
In conclusion, tumor-activated γδ T cells can induce adaptive immune responses through their APC-like functions, and these cells may be a potentially useful tool in the development of tumor vaccines and immunotherapy.
American Psychological Association (APA)
Mao, Chaoming& Mou, Xiao& Zhou, Yuepeng& Yuan, Guoyue& Xu, Chengcheng& Liu, Hongli…[et al.]. 2014. Tumor-Activated T C R γ δ + T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of T C R α β + T Cells via Their Antigen-Presenting Cell-Like Effects. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040918
Modern Language Association (MLA)
Mao, Chaoming…[et al.]. Tumor-Activated T C R γ δ + T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of T C R α β + T Cells via Their Antigen-Presenting Cell-Like Effects. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040918
American Medical Association (AMA)
Mao, Chaoming& Mou, Xiao& Zhou, Yuepeng& Yuan, Guoyue& Xu, Chengcheng& Liu, Hongli…[et al.]. Tumor-Activated T C R γ δ + T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of T C R α β + T Cells via Their Antigen-Presenting Cell-Like Effects. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040918