The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis
Joint Authors
Batycka-Baran, A.
Maj, J.
Wolf, R.
Szepietowski, J. C.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The pathognesis of psoriasis still remains not fully elucidated.
Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease.
Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules that provide the first line of defense against invading pathogens.
In recent years, the novel functions of AMPs have been identified.
There are three subclasses among AMPs that have gained the special interest as a potentially important player in the pathogenesis of psoriasis: cathelicidin, S100 proteins, and defensins.
These AMPs have been shown to modulate and trigger host immune response in psoriasis acting as interplayer between innate and adaptive immune mechanisms.
Overexpressed in psoriatic lesions, they prime immune cells for enhanced production of proinflammatory mediators and act as chemoattractant for leukocytes.
Therefore, the novel term describing AMPs alarmins has been suggested.
As multifunctional player in pathogenesis of psoriasis, AMPs may constitute potential target for therapeutic interventions.
However, further investigations are required to establish the methods of downregulation of the aberrant proinflammatory functions of AMPs without increasing the risk of infections.
American Psychological Association (APA)
Batycka-Baran, A.& Maj, J.& Wolf, R.& Szepietowski, J. C.. 2014. The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040926
Modern Language Association (MLA)
Batycka-Baran, A.…[et al.]. The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040926
American Medical Association (AMA)
Batycka-Baran, A.& Maj, J.& Wolf, R.& Szepietowski, J. C.. The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040926