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Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation
Joint Authors
Luo, Xiao-Hua
Chang, Ying-Jun
Huang, Xiao-Jun
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT).
CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning.
CMV infection commonly occurs following impaired IR of T cell and its subsets.
Here, we discuss the factors that influence IR based on currently available evidence.
Adoptive transfer of donor T cells to improve CMV-specific IR is discussed.
One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D−/R+).
Stem cell source and donor age are other important factors.
Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered.
The effects of varying degrees of HLA disparity and conditioning regimens are more controversial.
As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.
American Psychological Association (APA)
Luo, Xiao-Hua& Chang, Ying-Jun& Huang, Xiao-Jun. 2014. Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040927
Modern Language Association (MLA)
Luo, Xiao-Hua…[et al.]. Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040927
American Medical Association (AMA)
Luo, Xiao-Hua& Chang, Ying-Jun& Huang, Xiao-Jun. Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040927