A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent PrognosticPredictive Factor in Untreated Non-Small Lung Cancer Patients
Joint Authors
Vetsika, Eleni-Kyriaki
Koinis, Filippos
Gioulbasani, Marianthi
Aggouraki, Despoina
Koutoulaki, Anna
Skalidaki, Eirini
Mavroudis, Dimitris
Kotsakis, Athanasios
Georgoulias, Vassilios A.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of cells with immunosuppressive properties and might confer to worse prognosis in cancer patients.
The presence of phenotypically newly described subpopulations of MDSCs and their association with the clinical outcome were investigated in non-small cell lung cancer (NSCLC) patients.
The percentages and correlation between MDSCs and distinct immune cells in the peripheral blood of 110 chemotherapy-naive patients before treatment and healthy controls were investigated using flow cytometry.
Two monocytic [CD14+CD15−CD11b+CD33+HLA-DR−Lin− and CD14+CD15+CD11b+CD33+HLA-DR−Lin−] and a granulocytic [CD14−CD15+CD11b+CD33+HLA-DR−Lin−] subpopulations of MDSCs were identified, expressing inducible nitric oxide synthase, and reactive oxygen species, respectively.
Increased percentages of both monocytic-MDSCs’ subpopulations were inversely correlated to dendritic/monocyte levels ( P ≤ 0.04 ) , while granulocytic-MDSCs were inversely correlated to CD4+ T cells ( P = 0.006 ) .
Increased percentages of monocytic-MDSCs were associated with worse response to treatment ( P = 0.02 ) and patients with normal levels of CD14+CD15+CD11b+CD33+HLA-DR−Lin− had longer overall survival and progression free-survival compared to those with high levels ( P = 0.008 and P = 0.005 , resp.).
Multivariate analysis revealed that the increased percentages of CD14+CD15+CD11b+CD33+HLA-DR−Lin− MDSCs were independently associated with decreased progression free-survival and overall survival.
The data provide evidence that increased percentages of new monocytic-MDSCs’ subpopulations in advanced NSCLC patients are associated with an unfavourable clinical outcome.
American Psychological Association (APA)
Vetsika, Eleni-Kyriaki& Koinis, Filippos& Gioulbasani, Marianthi& Aggouraki, Despoina& Koutoulaki, Anna& Skalidaki, Eirini…[et al.]. 2014. A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent PrognosticPredictive Factor in Untreated Non-Small Lung Cancer Patients. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040938
Modern Language Association (MLA)
Vetsika, Eleni-Kyriaki…[et al.]. A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent PrognosticPredictive Factor in Untreated Non-Small Lung Cancer Patients. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040938
American Medical Association (AMA)
Vetsika, Eleni-Kyriaki& Koinis, Filippos& Gioulbasani, Marianthi& Aggouraki, Despoina& Koutoulaki, Anna& Skalidaki, Eirini…[et al.]. A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent PrognosticPredictive Factor in Untreated Non-Small Lung Cancer Patients. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040938