Genetic Diversity of MSP1 Block 2 of Plasmodium vivax Isolates from Manaus (Central Brazilian Amazon)
Joint Authors
Barbosa Filho, Roberto Alexandre Alves
Soares, Leidiane Amorim
Evangelista, Janaína
Sousa, Luciana Pereira de
Chaves, Yury
Lacerda, Marcus Vinícius
Almeida, Maria E.
Mariuba, Luis A.
Nogueira, Paulo Afonso
Orlandi, Patrícia Puccinelli
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The diversity of MSP1 in both Plasmodium falciparum and P.
vivax is presumed be associated to parasite immune evasion.
In this study, we assessed genetic diversity of the most variable domain of vaccine candidate N-terminal PvMSP1 (Block 2) in field isolates of Manaus.
Forty-seven blood samples the polymorphism of PvMSP1 Block 2 generates four fragment sizes.
In twenty-eight of them, sequencing indicated seven haplotypes of PvMSP1 Block 2 circulating among field isolates.
Evidence of striking exchanges was observed with two stretches flanking the repeat region and two predicted recombination sites were described.
Single nucleotide polymorphisms determined with concurrent infections per patient indicated that nonsynonymous substitutions occurred preferentially in the repeat-rich regions which also were predicted as B-cell epitopes.
The comprehensive understanding of the genetic diversity of the promising Block 2 associated with clinical immunity and a reduced risk of infection by Plasmodium vivax would be important for the rationale of malaria vaccine designs.
American Psychological Association (APA)
Soares, Leidiane Amorim& Evangelista, Janaína& Orlandi, Patrícia Puccinelli& Almeida, Maria E.& Sousa, Luciana Pereira de& Chaves, Yury…[et al.]. 2014. Genetic Diversity of MSP1 Block 2 of Plasmodium vivax Isolates from Manaus (Central Brazilian Amazon). Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040941
Modern Language Association (MLA)
Soares, Leidiane Amorim…[et al.]. Genetic Diversity of MSP1 Block 2 of Plasmodium vivax Isolates from Manaus (Central Brazilian Amazon). Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040941
American Medical Association (AMA)
Soares, Leidiane Amorim& Evangelista, Janaína& Orlandi, Patrícia Puccinelli& Almeida, Maria E.& Sousa, Luciana Pereira de& Chaves, Yury…[et al.]. Genetic Diversity of MSP1 Block 2 of Plasmodium vivax Isolates from Manaus (Central Brazilian Amazon). Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040941