The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases
Joint Authors
Curi, Rui
Ferreira, Caroline Marcantonio
Vieira, Angélica Thomaz
Vinolo, Marco Aurelio Ramirez
Oliveira, Fernando A.
Martins, Flaviano dos Santos
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens.
Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis.
Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity.
Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms.
Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases.
The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases.
American Psychological Association (APA)
Ferreira, Caroline Marcantonio& Vieira, Angélica Thomaz& Vinolo, Marco Aurelio Ramirez& Oliveira, Fernando A.& Curi, Rui& Martins, Flaviano dos Santos. 2014. The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040952
Modern Language Association (MLA)
Ferreira, Caroline Marcantonio…[et al.]. The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040952
American Medical Association (AMA)
Ferreira, Caroline Marcantonio& Vieira, Angélica Thomaz& Vinolo, Marco Aurelio Ramirez& Oliveira, Fernando A.& Curi, Rui& Martins, Flaviano dos Santos. The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040952