Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population
Joint Authors
Padilla-Gutiérrez, Jorge Ramón
Flores-Salinas, Hector Enrique
Valle, Yeminia
García-González, Ilian Janet
Valdés-Alvarado, Emmanuel
Sandoval-Pinto, Elena
Valdez-Haro, Angélica
De la Cruz-Mosso, Ulises
Muñoz-Valle, José Francisco
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The macrophage migration inhibitory factor (MIF) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS).
MIF has a CATT short tandem repeat (STR) at position −794 that might be involved in its expression rate.
The aim of this study was to investigate the association between the −794 CATT5–8 MIF gene polymorphism and susceptibility to ACS in a western Mexican population.
This research included 200 ACS patients classified according to the criteria of the American College of Cardiology (ACC) and 200 healthy subjects (HS).
The −794 CATT5–8 MIF gene polymorphism was analyzed using a conventional polymerase chain reaction (PCR) technique.
The 6 allele was the most frequent in both groups (ACS: 54% and HS: 57%).
The most common genotypes in ACS patients and HS were 6/7 and 6/6, respectively, and a significant association was found between the 6/7 genotype and susceptibility to ACS (68% versus 47% in ACS and HS, resp., P=0.03).
We conclude that the 6/7 genotype of the MIF −794 CATT5–8 polymorphism is associated with susceptibility to ACS in a western Mexican population.
American Psychological Association (APA)
Valdés-Alvarado, Emmanuel& Muñoz-Valle, José Francisco& Valle, Yeminia& Sandoval-Pinto, Elena& García-González, Ilian Janet& Valdez-Haro, Angélica…[et al.]. 2014. Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040966
Modern Language Association (MLA)
Valdés-Alvarado, Emmanuel…[et al.]. Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population. Journal of Immunology Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040966
American Medical Association (AMA)
Valdés-Alvarado, Emmanuel& Muñoz-Valle, José Francisco& Valle, Yeminia& Sandoval-Pinto, Elena& García-González, Ilian Janet& Valdez-Haro, Angélica…[et al.]. Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040966