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The TregTh17 Paradigm in Lung Cancer
Joint Authors
Liu, Guang-Nan
Wei, Jin-Ru
Zhong, Xiao-Ning
Duan, Min-Chao
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pathogenic mechanisms underlying the development of lung cancer are very complex and not yet entirely clarified.
T lymphocytes and their immune-regulatory cytokines play a pivotal role in controlling tumor growth and metastasis.
Following activation by unique cytokines, CD4+ T helper cells differentiate into Th1, Th2, Th17, and regulatory T cells (Tregs).
Traditionally, research in lung cancer immunity has focused almost exclusively on Th1/Th2 cell balance.
Recently, Th17 cells and Tregs represent an intriguing issue to be addressed in lung cancer pathogenesis.
Tregs play an important role in the preservation of self-tolerance and modulation of overall immune responses against tumor cells.
Th17 cells directly or via other proinflammatory cytokines modulate antitumor immune responses.
Notably, there is a close relation between Tregs and Th17 cells.
However, the possible interaction between these subsets in lung cancer remains to be elucidated.
In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent a useful tool for lung cancer treatment in the future.
The purpose of this review is to discuss recent findings of the role of these novel populations in lung cancer immunity and to highlight the pleiotropic effects of these subsets on the development and regulation of lung cancer.
American Psychological Association (APA)
Duan, Min-Chao& Zhong, Xiao-Ning& Liu, Guang-Nan& Wei, Jin-Ru. 2014. The TregTh17 Paradigm in Lung Cancer. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040968
Modern Language Association (MLA)
Duan, Min-Chao…[et al.]. The TregTh17 Paradigm in Lung Cancer. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040968
American Medical Association (AMA)
Duan, Min-Chao& Zhong, Xiao-Ning& Liu, Guang-Nan& Wei, Jin-Ru. The TregTh17 Paradigm in Lung Cancer. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040968