Transcriptional and Posttranscriptional Regulations of the HLA-G Gene
Joint Authors
Moreau, Philippe
Castelli, Erick C.
Veiga-Castelli, Luciana C.
Yaghi, Layale
Donadi, Eduardo Antônio
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
HLA-G has a relevant role in immune response regulation.
The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties.
The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-γ and NF-κB, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident.
At least three variable sites in the 3′ untranslated region have been studied that may influence HLA-G expression by modifying mRNA stability or microRNA binding sites, including the 14-base pair insertion/deletion, +3142C/G and +3187A/G polymorphisms.
Other polymorphic sites have been described, but there are no functional studies on them.
The HLA-G coding region polymorphisms might influence isoform production and at least two null alleles with premature stop codons have been described.
We reviewed the structure of the HLA-G promoter region and its implication in transcriptional gene control, the structure of the HLA-G 3′UTR and the major actors of the posttranscriptional gene control, and, finally, the presence of regulatory elements in the coding region.
American Psychological Association (APA)
Castelli, Erick C.& Veiga-Castelli, Luciana C.& Yaghi, Layale& Moreau, Philippe& Donadi, Eduardo Antônio. 2014. Transcriptional and Posttranscriptional Regulations of the HLA-G Gene. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040969
Modern Language Association (MLA)
Castelli, Erick C.…[et al.]. Transcriptional and Posttranscriptional Regulations of the HLA-G Gene. Journal of Immunology Research No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1040969
American Medical Association (AMA)
Castelli, Erick C.& Veiga-Castelli, Luciana C.& Yaghi, Layale& Moreau, Philippe& Donadi, Eduardo Antônio. Transcriptional and Posttranscriptional Regulations of the HLA-G Gene. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040969