![](/images/graphics-bg.png)
Inhibition of Neutrophil CollagenaseMMP-8 and Gelatinase BMMP-9 and Protection against Endotoxin Shock
Joint Authors
Opdenakker, G.
Qiu, Zheng
Chen, Jianghai
Xu, Hanmei
Van den Steen, Philippe E.
Wang, Min
Hu, Jialiang
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9).
After activation, these enzymes cleave extracellular matrix components and cytokines and thus may contribute to shock syndrome development.
MMP inhibitors have been suggested as immunotherapy of endotoxin shock.
However, little is known about the therapeutic time window of MMP inhibition.
Here, a sublethal endotoxin shock mouse model was used to evaluate the effect of an MMP inhibiting peptide (P2) after intravenous or intraperitoneal injection and to study the time window between LPS and inhibitor injections.
With the use of a specific ELISA the plasma P2 concentrations were monitored.
Whereas we corroborated the treatment strategy of MMP targeting in endotoxin shock with a new inhibitor, we also demonstrated that the time window, within which effective MMP inhibition increased the survival rates, is rather limited.
American Psychological Association (APA)
Qiu, Zheng& Chen, Jianghai& Xu, Hanmei& Van den Steen, Philippe E.& Opdenakker, G.& Wang, Min…[et al.]. 2014. Inhibition of Neutrophil CollagenaseMMP-8 and Gelatinase BMMP-9 and Protection against Endotoxin Shock. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040972
Modern Language Association (MLA)
Qiu, Zheng…[et al.]. Inhibition of Neutrophil CollagenaseMMP-8 and Gelatinase BMMP-9 and Protection against Endotoxin Shock. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040972
American Medical Association (AMA)
Qiu, Zheng& Chen, Jianghai& Xu, Hanmei& Van den Steen, Philippe E.& Opdenakker, G.& Wang, Min…[et al.]. Inhibition of Neutrophil CollagenaseMMP-8 and Gelatinase BMMP-9 and Protection against Endotoxin Shock. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040972