Association of Helicobacter pylori and iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis
Joint Authors
Sharkova, Tatyana V.
Potapova, Oxana V.
Belyaeva, Yana Yu.
Shkurupiy, Vyacheslav A.
Cherdantseva, Liliya
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Helicobacter pylori is one of the most common causes of chronic gastritis.
With the development of the disease cellular inflammatory infiltrates composed of lymphocytes, plasma cells, and macrophages are formed in epithelium and lamina propria of the stomach.
These cells are capable of secreting a number of active substances, including inducible nitric oxide synthase (iNOS).
We examined the relationship between H.
pylori and secretion of iNOS by cells of inflammatory infiltrates in chronic gastritis by light microscopy and immunohistochemistry.
The data obtained indicate that stimulation of H.
pylori immune system cells of the host organism during development of chronic gastritis causes increase in number of macrophages and lymphocytes in the inflammatory infiltrate of the gastric mucosa.
This is accompanied with increased expression of inducible NO-synthase with excess free radicals in the tissues, which leads to secondary alterations and exacerbates the inflammation with impaired regeneration processes.
American Psychological Association (APA)
Cherdantseva, Liliya& Potapova, Oxana V.& Sharkova, Tatyana V.& Belyaeva, Yana Yu.& Shkurupiy, Vyacheslav A.. 2014. Association of Helicobacter pylori and iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1040976
Modern Language Association (MLA)
Cherdantseva, Liliya…[et al.]. Association of Helicobacter pylori and iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis. Journal of Immunology Research No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1040976
American Medical Association (AMA)
Cherdantseva, Liliya& Potapova, Oxana V.& Sharkova, Tatyana V.& Belyaeva, Yana Yu.& Shkurupiy, Vyacheslav A.. Association of Helicobacter pylori and iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1040976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040976