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Reestablishment of Active Immunity against HBV Graft Reinfection after Liver Transplantation for HBV-Related End Stage Liver Disease
Joint Authors
Lu, Shi-Chun
Jiang, Tao
Lai, Wei
Liu, Yuan
Zhang, Jing
Zeng, Dao-Bing
Li, Chuan-Yun
Wang, Meng-Long
Lin, Dong-Dong
Zhu, Yue
Li, You-Ping
Li, Ning
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The aim of this study was to establish a hepatitis B virus (HBV) vaccination protocol among orthotopic liver transplantation (OLT) recipients under the coverage of a low-dose hepatitis B immunoglobulin (HBIG) combined with an antiviral agent prophylaxis protocol.
Method.
Two hundred OLT recipients were included in this study.
The vaccine was injected at months 0, 1, 2, and 6.
Low-dose HBIG combined with antiviral agent prophylaxis protocol was continued before reestablishment of active immunity against HBV in order to maintain a steady anti-HBs titer.
Results.
Active immunity against HBV was reestablished in 50 patients, for an overall response rate of 25%.
Of the 50 patients, 24 discontinued HBIG without any HBV graft reinfection during a follow-up period of 26.13 ± 7.05 months.
21 patients discontinued both HBIG and antiviral agents during a follow-up period of 39.86 ± 15.47 months, and 4 patients among them appeared to be HBsAg positive.
There was no recipient death or graft loss because of HBV reinfection.
Conclusions.
Vaccination preventing HBV reinfection for OLT recipients is feasible.
The strategy withdrawal of HBIG with induction of active immunity against hepatitis B is reasonable for long-term survivors of OLT; however, discontinuation nucleoside analogues should be cautious.
American Psychological Association (APA)
Lu, Shi-Chun& Jiang, Tao& Lai, Wei& Liu, Yuan& Zhang, Jing& Zeng, Dao-Bing…[et al.]. 2014. Reestablishment of Active Immunity against HBV Graft Reinfection after Liver Transplantation for HBV-Related End Stage Liver Disease. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040978
Modern Language Association (MLA)
Lu, Shi-Chun…[et al.]. Reestablishment of Active Immunity against HBV Graft Reinfection after Liver Transplantation for HBV-Related End Stage Liver Disease. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040978
American Medical Association (AMA)
Lu, Shi-Chun& Jiang, Tao& Lai, Wei& Liu, Yuan& Zhang, Jing& Zeng, Dao-Bing…[et al.]. Reestablishment of Active Immunity against HBV Graft Reinfection after Liver Transplantation for HBV-Related End Stage Liver Disease. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040978