Model for Vaccine Design by Prediction of B-Epitopes of IEDB Given Perturbations in Peptide Sequence, In Vivo Process, Experimental Techniques, and Source or Host Organisms
Joint Authors
González-Díaz, Humberto
Pérez-Montoto, Lázaro G.
Ubeira, Florencio M.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Perturbation methods add variation terms to a known experimental solution of one problem to approach a solution for a related problem without known exact solution.
One problem of this type in immunology is the prediction of the possible action of epitope of one peptide after a perturbation or variation in the structure of a known peptide and/or other boundary conditions (host organism, biological process, and experimental assay).
However, to the best of our knowledge, there are no reports of general-purpose perturbation models to solve this problem.
In a recent work, we introduced a new quantitative structure-property relationship theory for the study of perturbations in complex biomolecular systems.
In this work, we developed the first model able to classify more than 200,000 cases of perturbations with accuracy, sensitivity, and specificity >90% both in training and validation series.
The perturbations include structural changes in >50000 peptides determined in experimental assays with boundary conditions involving >500 source organisms, >50 host organisms, >10 biological process, and >30 experimental techniques.
The model may be useful for the prediction of new epitopes or the optimization of known peptides towards computational vaccine design.
American Psychological Association (APA)
González-Díaz, Humberto& Pérez-Montoto, Lázaro G.& Ubeira, Florencio M.. 2014. Model for Vaccine Design by Prediction of B-Epitopes of IEDB Given Perturbations in Peptide Sequence, In Vivo Process, Experimental Techniques, and Source or Host Organisms. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040979
Modern Language Association (MLA)
González-Díaz, Humberto…[et al.]. Model for Vaccine Design by Prediction of B-Epitopes of IEDB Given Perturbations in Peptide Sequence, In Vivo Process, Experimental Techniques, and Source or Host Organisms. Journal of Immunology Research No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1040979
American Medical Association (AMA)
González-Díaz, Humberto& Pérez-Montoto, Lázaro G.& Ubeira, Florencio M.. Model for Vaccine Design by Prediction of B-Epitopes of IEDB Given Perturbations in Peptide Sequence, In Vivo Process, Experimental Techniques, and Source or Host Organisms. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040979