The Intensity of Radiotherapy-Elicited Immune Response Is Associated with Esophageal Cancer Clearance
Joint Authors
Han, Su-xia
He, Chen-chen
Guo, Xi-jing
Ma, Jin-lu
Jin, Long
Li, Yao-Dong
Liu, Rui
Yang, Yun-Yi
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Radiation therapy is one of the standard therapeutic modalities for esophageal cancer, achieving its main antitumor efficacy through DNA damage.
However, accumulating evidence shows that radiotherapy can substantially alter the tumor microenvironment, particularly with respect to its effects on immune cells.
We hypothesized that the immune response elicited by radiotherapy may be as important as the radiation itself for successful treatment.
More specifically, immunomodulatory cytokines may enhance the effectiveness of radiotherapy.
To investigate this hypothesis, we measured changes in the serum interferon-gamma (IFN-γ) and interleukin-2 (IL-2) concentrations during radiotherapy and compared these modifications with outcomes.
We found that serum concentrations of IL-2 and IFN-γ were positively associated with local response to radiotherapy in esophageal cancer.
More generally, the intensity of the radiotherapy-elicited immune response was positively associated with local response to radiotherapy in esophageal cancer.
Changes in serum IL-2 and IFN-γ concentrations were further associated with increased risks of acute hematologic toxicity and acute organ toxicity of the esophagus, lung, and skin.
These results suggest that deciphering the mechanisms of radiotherapy-elicited immune response may help in the development of therapeutic interventions that would enhance the efficacy of radiotherapy and convert some ineffective responses to effective responses.
American Psychological Association (APA)
Ma, Jin-lu& Jin, Long& Li, Yao-Dong& He, Chen-chen& Guo, Xi-jing& Liu, Rui…[et al.]. 2014. The Intensity of Radiotherapy-Elicited Immune Response Is Associated with Esophageal Cancer Clearance. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040984
Modern Language Association (MLA)
Ma, Jin-lu…[et al.]. The Intensity of Radiotherapy-Elicited Immune Response Is Associated with Esophageal Cancer Clearance. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040984
American Medical Association (AMA)
Ma, Jin-lu& Jin, Long& Li, Yao-Dong& He, Chen-chen& Guo, Xi-jing& Liu, Rui…[et al.]. The Intensity of Radiotherapy-Elicited Immune Response Is Associated with Esophageal Cancer Clearance. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040984