Current Vaccine Trials in Glioblastoma: A Review
Joint Authors
Lim, Michael
Xu, Linda W.
Chow, Kevin K. H.
Li, Gordon
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glioblastoma (GBM) is the most common primary brain tumor, and despite aggressive therapy with surgery, radiation, and chemotherapy, average survival remains at about 1.5 years.
The highly infiltrative and invasive nature of GBM requires that alternative treatments for this disease be widespread and targeted to tumor cells.
Immunotherapy in the form of tumor vaccines has the potential to meet this need.
Vaccines against GBM hold the promise of triggering specific and systemic antitumor immune responses that may be the key to eradicating this unrelenting cancer.
In this review, we will discuss past and present clinical trials of various GBM vaccines and their potential impact on the future care of GBM patients.
There have been many promising phase I and phase II GBM vaccine studies that have led to ongoing and upcoming phase III trials.
If the results of these randomized trials show a survival benefit, immunotherapy will become a standard part of the treatment of this devastating disease.
American Psychological Association (APA)
Xu, Linda W.& Chow, Kevin K. H.& Lim, Michael& Li, Gordon. 2014. Current Vaccine Trials in Glioblastoma: A Review. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040985
Modern Language Association (MLA)
Xu, Linda W.…[et al.]. Current Vaccine Trials in Glioblastoma: A Review. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040985
American Medical Association (AMA)
Xu, Linda W.& Chow, Kevin K. H.& Lim, Michael& Li, Gordon. Current Vaccine Trials in Glioblastoma: A Review. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040985