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Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus
Joint Authors
Li, Jing
Leng, Xiaomei
Li, Zhijun
Ye, Zhizhong
Li, Caifeng
Li, Xiaofeng
Zhu, Ping
Wang, Zhengang
Zheng, Yi
Li, Xiangpei
Zhang, Miaojia
Tian, Xin-Ping
Li, Mengtao
Zhao, Jiuliang
Zhao, Yan
Zeng, Xiaofeng
Zhang, Fengchun
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort.
Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; between anti-RNP antibody, anti-SSA antibody, and pulmonary arterial hypertension (PAH); between anti-SSB antibody and hematologic involvement; and between anti-dsDNA antibody and nephropathy.
APL antibody was associated with hematologic involvement, interstitial lung disease, and a lower prevalence of oral ulcerations (P<0.05).
Associations were also found between anti-dsDNA antibody and a lower prevalence of photosensitivity, and between anti-SSA antibody and a lower prevalence of nephropathy (P<0.05).
Most of these findings were consistent with other studies in the literature but this study is the first report on the association between anti-SSA and a lower prevalence of nephropathy.
The correlations of specific autoantibodies and clinical manifestations could provide clues for physicians to predict organ damages in SLE patients.
We suggest that a thorough screening of autoantibodies should be carried out when the diagnosis of SLE is established, and repeated echocardiography annually in SLE patients with anti-RNP or anti-SSA antibody should be performed.
American Psychological Association (APA)
Li, Jing& Leng, Xiaomei& Li, Zhijun& Ye, Zhizhong& Li, Caifeng& Li, Xiaofeng…[et al.]. 2014. Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040987
Modern Language Association (MLA)
Li, Jing…[et al.]. Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040987
American Medical Association (AMA)
Li, Jing& Leng, Xiaomei& Li, Zhijun& Ye, Zhizhong& Li, Caifeng& Li, Xiaofeng…[et al.]. Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040987