Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs
Joint Authors
Kremláček, J.
Borska, Lenka
Palicka, Vladimir
Chmelarova, Marcela
Hamakova, Kvetoslava
Borsky, Pavel
Fiala, Zdenek
Krejsek, Jan
Andrys, Ctirad
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Some specific antibodies indicate the presence of antigenic structures on DNA (DNA adducts) that can play an important role in the process of mutagenesis and/or carcinogenesis.
They indicate the presence of increased genotoxic potential (hazard) prior to the formation of disease (primary prevention).
The present study was focused on the serum level of benzo[a]pyrene 7,8-diol-9,10-epoxide-DNA adducts antibodies (anti-BPDE-DNA) in psoriatic patients ( n = 55 ) dermally exposed to different levels of polycyclic aromatic hydrocarbons (PAHs).
The general goal of the study was to contribute to better understanding of the value of the assumed biomarker (anti-BPDE-DNA) for evaluation of the organism's answer to genotoxic exposure to PAHs.
Elevated level of exposure to PAHs resulted in the increased level of anti-BPDE-DNA.
However, almost all levels of anti-BPDE-DNA ranged within the field of low values.
Both variants of GT (CCT-3% and CCT-5%) induced higher expression of anti-BPDE-DNA in the group of nonsmokers.
Significant relations between the level of anti-BPDE-DNA and PASI score, total duration of the therapy, or time of UVR exposure were not found.
Further studies are needed to reduce interpretation uncertainty of this promising bioindicator.
American Psychological Association (APA)
Borska, Lenka& Andrys, Ctirad& Krejsek, Jan& Palicka, Vladimir& Chmelarova, Marcela& Hamakova, Kvetoslava…[et al.]. 2014. Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040995
Modern Language Association (MLA)
Borska, Lenka…[et al.]. Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs. Journal of Immunology Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040995
American Medical Association (AMA)
Borska, Lenka& Andrys, Ctirad& Krejsek, Jan& Palicka, Vladimir& Chmelarova, Marcela& Hamakova, Kvetoslava…[et al.]. Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040995