The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets
Joint Authors
Morales-Montor, Jorge
Nava-Castro, Karen
Palacios-Arreola, M. Isabel
Castro, Julieta I.
García-Zepeda, Eduardo
Carrero, Julio C.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses.
The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effects.
Complicating the system further, these effects depend on the cellular milieu.
In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-directed metastasis, they also mediate other phenomena related to disease progression, such as angiogenesis and even chemoresistance.
Therefore, the chemokine system is becoming a target in cancer therapeutics.
We review the emerging data and correlations between chemokines/chemokine receptors and breast cancer, their implications in cancer progression, and possible therapeutic strategies that exploit the chemokine system.
American Psychological Association (APA)
Palacios-Arreola, M. Isabel& Nava-Castro, Karen& Castro, Julieta I.& García-Zepeda, Eduardo& Carrero, Julio C.& Morales-Montor, Jorge. 2014. The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040998
Modern Language Association (MLA)
Palacios-Arreola, M. Isabel…[et al.]. The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040998
American Medical Association (AMA)
Palacios-Arreola, M. Isabel& Nava-Castro, Karen& Castro, Julieta I.& García-Zepeda, Eduardo& Carrero, Julio C.& Morales-Montor, Jorge. The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040998