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Protective Effects of Baicalin on Decidua Cells of LPS-Induced Mice Abortion
Joint Authors
Zhao, Yantao
Zhong, Xiuhui
Wang, Xiaodan
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The study was carried out to investigate the protective effects of Baicalin on decidual cells of LPS-induced abortion mice.
In the in vitro experiment, the decidual cells were cultured by uterus tissue mass cultivation sampled at day 6 of pregnancy, and gradient concentrations of LPS were used to determine the optimal LPS concentration of the injured decidual cells model.
The injured decidual cells were treated with Baicalin (4 μg/mL) to determine the protective role of Baicalin.
In the in vivo experiment, lipopolysaccharide (LPS) was injected intravenously via the tail vein to induce abortion at day 6 of pregnancy, and the mice were given different concentrations of Baicalin by oral gavage consecutively at days 7 to 8 of pregnancy.
On day 9 of gestation, the mice were sacrificed.
The TNF and progesterone contents in the serum were assayed by ELISA.
The results clearly revealed that Baicalin can prevent the injury to decidual cells from LPS dose dependently, TNF was decreased significantly ( P < 0.01 ) compared to LPS group, and there was no effect on the progesterone.
These findings suggest that Baicalin has protective effects on the injured decidual cells in the pregnant mice.
American Psychological Association (APA)
Wang, Xiaodan& Zhao, Yantao& Zhong, Xiuhui. 2014. Protective Effects of Baicalin on Decidua Cells of LPS-Induced Mice Abortion. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1041003
Modern Language Association (MLA)
Wang, Xiaodan…[et al.]. Protective Effects of Baicalin on Decidua Cells of LPS-Induced Mice Abortion. Journal of Immunology Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1041003
American Medical Association (AMA)
Wang, Xiaodan& Zhao, Yantao& Zhong, Xiuhui. Protective Effects of Baicalin on Decidua Cells of LPS-Induced Mice Abortion. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1041003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041003