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Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors
Joint Authors
Vogt, Annabelle
Gonzalez-Carmona, Maria A.
Schmidt-Wolf, Ingo G. H.
Jäkel, Clara E.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Tumors of the gastrointestinal system represent a significant share of solid tumors worldwide.
Despite the advances in diagnosis and treatment, the prognosis of gastrointestinal tumors is still very poor and improved therapies are indispensable.
Cytokine-induced killer (CIK) cells are feasible for an immunotherapeutic approach as they are easily available and have an advantageous biologic profile; they are rapidly proliferating and their high cytotoxicity is non-MHC-restricted.
We summarize and discuss twenty recent clinical studies applying CIK cells for the treatment of gastric, pancreatic, hepatocellular, and colorectal cancer.
Autologous CIK cells were transfused intravenously, intraperitoneally, or via the common hepatic artery.
In all studies side effects and toxicity of CIK cell therapy were mild and easily controllable.
The combination of CIK cell therapy with conventional adjuvant or palliative therapies was superior to the standard therapy alone, indicating the benefit of CIK cell therapy for cancer patients.
Thus, CIK cells represent a promising immunotherapy for the treatment of gastrointestinal tumors.
The optimal treatment schedule and ideal combination with conventional therapies should be evaluated in further clinical studies.
American Psychological Association (APA)
Jäkel, Clara E.& Vogt, Annabelle& Gonzalez-Carmona, Maria A.& Schmidt-Wolf, Ingo G. H.. 2014. Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041006
Modern Language Association (MLA)
Jäkel, Clara E.…[et al.]. Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1041006
American Medical Association (AMA)
Jäkel, Clara E.& Vogt, Annabelle& Gonzalez-Carmona, Maria A.& Schmidt-Wolf, Ingo G. H.. Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041006