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Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+ T Cells of Patients with Relapsing-Remitting Multiple Sclerosis
Joint Authors
Meira, Maria
Sievers, Claudia
Hoffmann, Francine
Rasenack, Maria
Kuhle, Jens
Derfuss, Tobias
Kappos, Ludwig
Lindberg, Raija L. P.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a family of noncoding RNAs that play critical roles in the posttranscriptional regulation of gene expression.
Accumulating evidence supports their involvement in the pathogenesis of multiple sclerosis (MS).
Here, we compare miR-17 expressions in CD4+ T cells from relapsing-remitting (RR) MS patients treated with natalizumab versus untreated patients.
miR-17 was downregulated under natalizumab treatment and upregulated during relapse, therefore supporting a possible role of miR-17 in MS immunopathogenesis.
Downregulation of miR-17 was associated with upregulation of PTEN, BIM, E2F1, and p21 target genes.
In vitro miR-17 inhibition was associated with upregulation of the same targets and resulted in impaired CD4+ T cell activation and proliferation.
We further describe deregulated TGFBR2 expression in untreated patients versus healthy volunteers (HVs) and confirm in vitro the link between miR-17 and TGFBR2 expressions.
These findings support an effect of natalizumab on expression of specific miRNA and subsequent expression of genes involved in proliferation and control of the cell cycle.
American Psychological Association (APA)
Meira, Maria& Sievers, Claudia& Hoffmann, Francine& Rasenack, Maria& Kuhle, Jens& Derfuss, Tobias…[et al.]. 2014. Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+ T Cells of Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1041007
Modern Language Association (MLA)
Meira, Maria…[et al.]. Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+ T Cells of Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1041007
American Medical Association (AMA)
Meira, Maria& Sievers, Claudia& Hoffmann, Francine& Rasenack, Maria& Kuhle, Jens& Derfuss, Tobias…[et al.]. Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+ T Cells of Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1041007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041007